Drug distribution along the cochlea is strongly enhanced by low-frequency round window micro vibrations

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Distribution of low-frequency earthquakes accompanying the very low frequency earthquakes along the Ryukyu Trench

This study investigated the activity and distribution of low-frequency earthquakes (LFEs) accompanying the very low frequency earthquakes (VLFEs) in the central and southern Ryukyu Trench. This investigation was based on shortperiod seismometer waveforms obtained by the Japan Meteorological Agency from April 2004 to December 2015. The LFEs were detected using the Envelope Correlation Method, an...

متن کامل

Vibrations of low frequency over the precordium.

A method for taking tracings which represent actual movements of the precordium (displacement curves) or records which show waves proportional to the velocity of movement of the chest wall (velocity curves) is described. The equipment employed is readily available, and the method is easy to use. The displacement curves are nearly identical with cardiograms taken with a good optical setup, and t...

متن کامل

Pathologic Findings of the Cochlea in Labyrinthitis Ossificans Associated with the Round Window Membrane.

OBJECTIVE To quantitatively demonstrate and classify the histopathologic changes in the cochlea of the human temporal bones with labyrinthitis ossificans (LO). STUDY DESIGN Comparative human temporal bone study. SETTING Tertiary academic medical center. SUBJECTS AND METHODS We compared 23 temporal bone specimens from 19 deceased donors with LO associated with the round window membrane (RW...

متن کامل

Round Window Membrane and Delivery of Biologically Active Agents into the Cochlea

Establishing efficient methods for local administration of drugs to the inner ear has great clinical relevance for the management of inner ear disorders. However, the administration route remains a critical issue. The most feasible approach for a non invasive drug delivery to the inner ear is application of medication to the middle ear cavity on the promise that it will diffuse through the thin...

متن کامل

Low-frequency vibrations of DNA molecules.

A model for calculating the low-frequency modes in DNA molecules is presented. The present model is associated with the 'breathing' of a DNA molecule as well as its complementary hydrogen bonds. The calculated results show excellent agreement with the observed low-frequency wavenumber (30 cm-1). Consequently, such an internal motion as reflected in the proposed model might be the origin of the ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Drug Delivery

سال: 2021

ISSN: 1071-7544,1521-0464

DOI: 10.1080/10717544.2021.1943059